Metabolism and Biomarkers of Heterocyclic Aromatic Amines in Molecular Epidemiology Studies: Lessons Learned from Aromatic Amines

Metabolism of aromatic amino acids and amines.

Nitrosamines and Aromatic Amines

A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...

Heterocyclic Aromatic Amines Formation in Grilled Fatty Fish

The consumption of fish provides utilization of proteins of high biological value, certain minerals, and vitamins. Additionally, fish and fish oil are rich sources of omega-3 fatty acids. Sardine (Sardina pilchardus) and salmon (Salmo salar) are fish species rich in omega-3 PUFAs. On the other hand, fish is usually cooked in different ways before consumption and heat treatment can lead to undes...

Species differences in metabolism of heterocyclic aromatic amines, human exposure, and biomonitoring.

Heterocyclic aromatic amines (HAAs) are animal carcinogens and suspected human carcinogens which are formed in cooked foods at the low parts per billion level. HAAs in cooked meats were purified by either immunoaffinity chromatography or solid phase tandem extraction, which allowed for the simultaneous analysis of 11 HAAs by HPLC. The metabolism of two prominent HAAs, 2-amino-3,8-dimethylimidaz...

The Biochemistry of Aromatic Amines

1. 2-Naphthylhydroxylamine and 2-nitrosonaphthalene were present in urine of dogs but not of guinea pigs, hamsters, rabbits or rats dosed with 2-naphthylamine. N-Acetyl-2-naphthylhydroxylamine and its O-sulphonic acid and O-glucosiduronic acid were not detected in the urine of any of these species. 2. Bile from rats dosed with 2-naphthylamine contained (2-naphthylamine N-glucosid)uronic acid an...